Src may be involved in the anti-cancer effect of conjugated linoleic acid. Comment on: CLA reduces breast cancer cell growth and invasion through ER and PI3K/Akt pathways

Chem Biol Interact. 2010 Jul 30;186(2):250-1; author reply 252-3. doi: 10.1016/j.cbi.2010.03.052. Epub 2010 Apr 8.
No abstract available

Publication types

  • Comment
  • Letter

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Estrogen Receptor alpha / metabolism
  • Female
  • Humans
  • Linoleic Acids, Conjugated / pharmacology*
  • MAP Kinase Signaling System / drug effects
  • Neoplasm Invasiveness / prevention & control
  • PPAR gamma / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism
  • Proto-Oncogene Proteins c-akt / metabolism
  • Signal Transduction / drug effects
  • Somatomedins / metabolism
  • src-Family Kinases / metabolism*

Substances

  • Antineoplastic Agents
  • Estrogen Receptor alpha
  • Linoleic Acids, Conjugated
  • PPAR gamma
  • Somatomedins
  • Phosphatidylinositol 3-Kinases
  • src-Family Kinases
  • Proto-Oncogene Proteins c-akt