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World J Gastroenterol. 2010 Apr 14;16(14):1772-5.

Identification of cerebral response to balloon distention of the bile duct.

Author information

  • 1Department of Gastroenterology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. jinkans@juntendo.ac.jp

Abstract

AIM:

To identify the brain loci that process human biliary sensation.

METHODS:

In 6 patients (age range: 42-74 years; 4 men), who underwent percutaneous transhepatic biliary drainage (PTBD), the distal biliary tract was stimulated by repeatedly inflating the balloon of the PTBD catheter so that it reached volumes that produced a definite painless sensation. The functional magnetic resonance imaging (fMRI) of the cortical response to biliary sensation was examined.

RESULTS:

Biliary balloon stimulation elicited activation of the insular cortex, prefrontal cortex, and somatosensory cortex (P < 0.001).

CONCLUSION:

Biliary balloon stimulation evoked a cerebral cortical response detectable by fMRI.

PMID:
20380011
[PubMed - indexed for MEDLINE]
PMCID:
PMC2852827
Free PMC Article

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