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Nat Rev Mol Cell Biol. 2010 May;11(5):329-41. doi: 10.1038/nrm2882. Epub 2010 Apr 9.

The emerging mechanisms of isoform-specific PI3K signalling.

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Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London, UK.


Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal transduction pathways and affect many biological functions. A further level of complexity derives from the existence of eight PI3K isoforms, which are divided into class I, class II and class III PI3Ks. PI3K signalling has been implicated in metabolic control, immunity, angiogenesis and cardiovascular homeostasis, and is one of the most frequently deregulated pathways in cancer. PI3K inhibitors have recently entered clinical trials in oncology. A better understanding of how the different PI3K isoforms are regulated and control signalling could uncover their roles in pathology and reveal in which disease contexts their blockade could be most beneficial.

[Indexed for MEDLINE]

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