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Clin Colorectal Cancer. 2010 Apr;9(2):E1-4. doi: 10.3816/CCC.2010.n.026.

Chemotherapy resistance and retreatment: a dogma revisited.

Author information

1
Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston.

Abstract

The prevailing belief in cancer therapy is that retreatment with a given drug after the emergence of resistance is ineffective. Herein, we report several cases in which retreatment with drugs that had failed earlier in the disease trajectory caused renewed tumor regression. The possible biologic underpinnings that might explain this phenomenon are discussed.

PMID:
20378496
DOI:
10.3816/CCC.2010.n.026
[Indexed for MEDLINE]

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