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Curr Opin Immunol. 2010 Jun;22(3):274-8. doi: 10.1016/j.coi.2010.03.003. Epub 2010 Apr 6.

From the thymus to longevity in the periphery.

Author information

1
Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

Abstract

An important attribute of the adaptive immune system is the ability to remember a prior encounter with a pathogen; an ability termed immunological memory. Bigger, better, and stronger responses are mounted upon a secondary encounter with the pathogen potentially resulting in clearance of the infection before the development of disease. We will review recent advances in the field of memory CD8(+) T cell differentiation focusing on both intrinsic and extrinsic factors that govern the development of T cell memory.

PMID:
20378321
PMCID:
PMC2904522
DOI:
10.1016/j.coi.2010.03.003
[Indexed for MEDLINE]
Free PMC Article

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