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Int J Data Min Bioinform. 2010;4(1):91-108.

Identifying the overlapping complexes in protein interaction networks.

Author information

1
School of Information Science and Engineering, Central South University, Changsha 410083, China. limin@mail.csu.edu.cn

Abstract

Identification of protein complexes in large interaction networks is crucial to understanding principles of cellular organisation and predict protein functions. In this paper, a new algorithm of Identifying Protein Complexes based on Maximal Clique Extension (IPC-MCE) is proposed. The maximal clique is considered as the core of the protein complex. Proteins in a complex are classed into core vertices and peripheral vertices. The relation between the core vertices and peripheral vertices is measured by the Interaction Probability. The algorithm IPC-MCE is applied to the protein interaction network of Saccharomyces cerevisiae. Many well-known protein complexes are detected.

PMID:
20376924
[Indexed for MEDLINE]

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