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Arch Gynecol Obstet. 2011 Feb;283(2):397-9. doi: 10.1007/s00404-010-1449-6. Epub 2010 Apr 8.

Unilateral tubal twin ectopic pregnancy treated with single-dose methotrexate.

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Department of Obstetrics and Gynecology, Kahramanmaras Sutcu Imam University, Kahramanmaraş, Turkey.



Spontaneous tubal twin pregnancy is a rare condition with an incidence of 1 in every 125,000 pregnancies. We present the case of a unilateral tubal twin ectopic pregnancy treated with single-dose methotrexate.


A 26-year-old nulliparous woman was admitted to our clinic with a complaint of vaginal bleeding and leftside pelvic pain. Her serum β-human chorionic gonadotropin (β-hCG) level was 18,780 mIU/mL and ultrasound revealed tubal twin pregnancy of 7 weeks' gestation. Because her vital signs were stable and no sign of tubal rupture was present, we performed single-dose (100 mg) methotrexate intramuscularly. In the follow-up, serum β-hCG levels were found to be 7,600 mIU/ml on day 7, 948 mIU/ml on day 20, 126 mIU/ml on day 26 and <10 mIU/ml on day 42.


Methotrexate theraphy may be preferred in tubal twin ectopic pregnancies when the vital signs of the patient are stable and the fetal cardiac activities are negative.

[Indexed for MEDLINE]

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