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J Innate Immun. 2009;1(6):592-8. doi: 10.1159/000235583. Epub 2009 Aug 14.

Divergent effects on phagocytosis by macrophage-derived oxygen radicals.

Author information

1
Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden.

Abstract

Clearance of senescent cells from damaged tissue is a crucial step to successfully resolve an inflammatory response. Poor clearance has been attributed to defects in neutrophil apoptosis, a process that is regulated in part by reactive oxygen species (ROS) produced by activated neutrophils. Using ROS-deficient and wild-type macrophages treated with extracellular ROS scavengers we demonstrate that macrophage-derived ROS also influence phagocytosis and do so by direct and indirect mechanisms.

PMID:
20375614
DOI:
10.1159/000235583
[Indexed for MEDLINE]
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