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J Innate Immun. 2009;1(5):435-45. doi: 10.1159/000226248. Epub 2009 Jun 24.

Measure and countermeasure: type I IFN (IFN-alpha/beta) antiviral response against West Nile virus.

Author information

1
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

Abstract

As a first line of defense after viral infection, host cells develop an intrinsic immune response to control virus dissemination and protect against serious infection. Recent experiments have shown a dominant role of the IFN-alpha/beta response in protection against lethal West Nile virus (WNV) by limiting the cellular and tissue tropism of infection. This review will focus on advances in identifying the host sensors that detect WNV and the adaptor molecules and signaling pathways that regulate the induction of IFN-alpha/beta defenses that limit WNV replication, spread and pathogenesis.

PMID:
20375601
PMCID:
PMC2920482
DOI:
10.1159/000226248
[Indexed for MEDLINE]
Free PMC Article

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