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J Innate Immun. 2009;1(4):335-9. doi: 10.1159/000191216. Epub 2009 Jan 8.

The c-src homologue Src64B is sufficient to activate the Drosophila cellular immune response.

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Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK.


The Drosophila larval cellular immune response involves cells (haemocytes) that can be recruited from a haematopoietic organ known as the lymph gland, as well as a sessile population of cells found just underneath the larval cuticle arranged in a segmental pattern. Overexpression of the Drosophila c-src homologue Src64B disrupts the sessile-haemocyte banding pattern. Though Src64B overexpression induced the formation of specialized haemocytes known as lamellocytes, its hyperactivation had no effect on circulating plasmatocyte concentration. Also, there is evidence of non-autonomous regulation as Src64B activity was observed in non-overexpressing plasmatocytes. Finally, Src64B overexpression induced F-actin formation and Jun kinase activation in plasmatocytes.

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