Format

Send to

Choose Destination
See comment in PubMed Commons below
Psychiatry Clin Neurosci. 2010 Jun;64(3):279-83. doi: 10.1111/j.1440-1819.2010.02079.x. Epub 2010 Mar 30.

Low serum HDL-cholesterol levels are associated with long symptom duration in patients with major depressive disorder.

Author information

1
Department of Psychiatry, Kuopio University Hospital, PO Box 1777, FIN-70210 Kuopio, Finland. soili.lehto@kuh.fi

Abstract

AIMS:

The purpose of the present study was to examine whether the association between depression and the serum high-density lipoprotein cholesterol (HDL-C) is modified by symptom duration.

METHODS:

Depressed patients (n = 88) and an age- and sex-matched group of healthy general population controls (n = 88) underwent a Structured Clinical Interview for DSM-IV (SCID), and depressed participants reported the duration of their symptoms. The serum levels of total cholesterol (TC), HDL-C, low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and non-HDL, and the ratios of LDL-C/HDL and TC/HDL-C were assessed.

RESULTS:

Major depressive disorder (MDD) subjects with a long symptom duration (>or=3 years) had lower levels of HDL-C compared with healthy controls or MDD subjects with a symptom duration <3 years. The likelihood for long symptom duration doubled for each 0.5-mmol/L decrease in HDL-C levels in regression models adjusted for age, gender, marital status, overweight, symptom severity, alcohol consumption, smoking, physical exercise, medication use, and non-HDL-C (P < 0.05).

CONCLUSIONS:

These findings suggest that a low serum HDL-C level, a risk factor for coronary heart disease, is specifically associated with long-term depressive symptomatology.

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center