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Biomarkers. 2010 Jun;15(4):345-52. doi: 10.3109/13547501003753881.

Temporal stability of urinary and plasma biomarkers of tobacco smoke exposure among cigarette smokers.

Author information

1
Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, MN 55455, USA. trc@cccs.umn.edu

Abstract

Intraindividual variability of measurements of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), nicotine, cotinine, and r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT) over time is uncertain. From 70 habitual smokers' plasma and urine sampled bimonthly for a year we analysed plasma for NNAL, cotinine and PheT, and urine for NNAL, cotinine and nicotine. We estimated the intraclass correlation coefficients (rho(I)) for each measurement. Plasma and creatinine-corrected urinary NNAL were stable (rho(I) > or =70%); plasma PheT and plasma and urinary total cotinine were fairly stable (rho(I) > or =50%), but urinary nicotine rho(I) approximately 40% was not. Except for nicotine, single measurements from plasma or urine adequately represent individual mean exposure over time.

PMID:
20374068
PMCID:
PMC2871960
DOI:
10.3109/13547501003753881
[Indexed for MEDLINE]
Free PMC Article

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