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Hum Psychopharmacol. 2010 Apr;25(3):222-9. doi: 10.1002/hup.1112.

Impact of the novel antidepressant agomelatine on disturbed sleep-wake cycles in depressed patients.

Author information

1
Sleep Unit, Raymond Poincaré Hospital, Garches, APHP, France. maria-antonia.quera-salva@rpc.aphp.fr

Abstract

BACKGROUND:

Disturbance of sleep-wake cycles is common in major depressive disorder (MDD), usually as insomnia, but also as hypersomnia or reduced daytime alertness. Agomelatine, an MT(1) and MT(2) receptor agonist and 5-HT(2C) receptor antagonist, represents a novel approach in MDD, with proven antidepressant efficacy and a positive impact on the sleep-wake cycle. We review the effects of agomelatine 25/50 mg/day on objective and subjective measures of the sleep-wake cycle in MDD.

SUBJECTIVE MEASURES:

Agomelatine improved all aspects of the sleep-wake cycle from as early as 1 week in randomized trials versus selective serotonin reuptake inhibitors and venlafaxine, particularly getting off to sleep and quality of sleep, with an improvement in daytime alertness.

OBJECTIVE MEASURES:

Agomelatine's effect on sleep architecture in MDD has been measured by polysomnography (PSG). There were significant improvements in sleep efficiency, slow-wave sleep (SWS), and the distribution of delta activity throughout the night, but no change in amount or latency of rapid eye movement (REM) sleep. Furthermore, the slow-wave sleep was resynchronized to the first sleep cycle of the night.

CONCLUSION:

Agomelatine, a novel antidepressant, improves disturbed sleep-wake cycles in MDD. The improvement of both nighttime sleep and daytime functioning with agomelatine are promising features of this antidepressant regarding the management of MDD.

PMID:
20373473
DOI:
10.1002/hup.1112
[Indexed for MEDLINE]
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