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Ann Neurol. 2010 Mar;67(3):398-404. doi: 10.1002/ana.21888.

Pregnancy increases the growth rates of World Health Organization grade II gliomas.

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1
Department of Neurosurgery, Sainte-Anne Hospital, 1 rue Cabanis, 75674 Paris Cedex 14, France. johanpallud@hotmail.com

Abstract

Twelve pregnancies in 11 adult women harboring World Health Organization (WHO) grade II gliomas (GIIGs) prior to pregnancy were reviewed to address whether pregnancy affects tumor growth using a quantitative approach of the radiological velocity of diametric expansion (VDE) on successive magnetic resonance images. VDE was significantly increased during pregnancy as compared to prepregnancy (p < 0.001) and to postdelivery (p = 0.012) periods. Pregnancy increases the radiological growth rates of GIIGs. An increase in seizure frequency was observed concomitantly in 40% of cases and further oncological treatment was started after delivery in 25% of cases.

PMID:
20373352
DOI:
10.1002/ana.21888
[Indexed for MEDLINE]
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