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Eur J Pediatr. 2010 Sep;169(9):1119-22. doi: 10.1007/s00431-010-1192-9. Epub 2010 Apr 8.

Evidence of Bordetella pertussis infection in vaccinated 1-year-old Danish children.

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Department of Pediatrics, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.


We measured IgA and IgG antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA) in sera from 203 1-year-old children who had received one to three doses of a monocomponent PT toxoid vaccine. Ten children (5%) had IgA antibody to PT indicating recent infection; seven of these children had received three doses of vaccine. PT IgA responders did not have significantly longer coughing episodes than PT IgA non-responders. Since an IgA antibody response occurs in only approximately 50% of infected children, the actual infection rate in our cohort is estimated to approximately 10%. The apparent high Bordetella pertussis infection rate in Danish infants suggests that the monocomponent PT toxoid vaccine used in Denmark has limited efficacy against B. pertussis infection. A prospective immunization study comparing a multi-component vaccine with the present monocomponent PT toxoid vaccine should be undertaken.

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