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Nat Rev Microbiol. 2010 May;8(5):328-39. doi: 10.1038/nrmicro2318. Epub 2010 Apr 7.

Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells.

Author information

1
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, Ohio 43210, USA. rikihisa.1@osu.edu

Abstract

Anaplasma spp. and Ehrlichia spp. cause several emerging human infectious diseases. Anaplasma phagocytophilum and Ehrlichia chaffeensis are transmitted between mammals by blood-sucking ticks and replicate inside mammalian white blood cells and tick salivary-gland and midgut cells. Adaptation to a life in eukaryotic cells and transmission between hosts has been assisted by the deletion of many genes that are present in the genomes of free-living bacteria (including genes required for the biosynthesis of lipopolysaccharide and peptidoglycan), by the acquisition of a cholesterol uptake pathway and by the expansion of the repertoire of genes encoding the outer-membrane porins and type IV secretion system. Here, I review the specialized properties and other adaptations of these intracellular bacteria.

PMID:
20372158
DOI:
10.1038/nrmicro2318
[Indexed for MEDLINE]

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