Format

Send to

Choose Destination
Cell Cycle. 2010 Apr 1;9(7):1291-4.

Reduced mortality and moderate alcohol consumption: the phospholipase D-mTOR connection.

Author information

1
Department of Biological Sciences, Hunter College of the City University of New York, New York, NY, USA. foster@genectr.hunter.cuny.edu

Abstract

Many studies have suggested that moderate alcohol consumption reduces mortality. There is also substantial evidence that lifespan is extended with suppression of TOR (target of rapamycin). It was reported recently that rapamycin is able to extend the lifespan of a mammal--implicating the mammalian TOR (mTOR). mTOR has a requirement for the lipid second messenger phosphatidic acid (PA), which is generated by phospholipase D (PLD). Therefore, in principle, suppression of PLD would be similar to treatment with rapamycin. Significantly, PLD utilizes ethanol preferentially over water in the hydrolysis reaction that ordinarily generates PA. In the presence of ethanol, phosphatidyl-ethanol is generated at the expense of PA leading to the suppression of mTOR. This reaction, known as the transphosphatidylation reaction, provides a mechanistic basis for the reduced mortality observed with moderate consumption of alcohol--that being the suppression of mTOR.

PMID:
20372065
PMCID:
PMC2957519
DOI:
10.4161/cc.9.7.11145
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center