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Cell. 2010 Apr 2;141(1):178-90. doi: 10.1016/j.cell.2010.02.039.

Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease.

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1
Vesalius Research Center, KU Leuven, Leuven B-3000, Belgium.

Abstract

Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of carcinogen-induced and transgenic tumor models as well as ocular neovascularization to report further evidence in support of our original findings of PlGF as a promising target for anticancer therapies. We present evidence for the efficacy of additional anti-PlGF antibodies and their ability to phenocopy genetic deficiency or silencing of PlGF in cancer and ocular disease but also show that not all anti-PlGF antibodies are effective. We also provide additional evidence for the specificity of our anti-PlGF antibody and experiments to suggest that anti-PlGF treatment will not be effective for all tumors and why. Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies.

PMID:
20371353
DOI:
10.1016/j.cell.2010.02.039
[Indexed for MEDLINE]
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