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Cell. 2010 Apr 2;141(1):39-51. doi: 10.1016/j.cell.2010.03.014.

Macrophage diversity enhances tumor progression and metastasis.

Author information

1
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Abstract

There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. During tumor initiation, they create an inflammatory environment that is mutagenic and promotes growth. As tumors progress to malignancy, macrophages stimulate angiogenesis, enhance tumor cell migration and invasion, and suppress antitumor immunity. At metastatic sites, macrophages prepare the target tissue for arrival of tumor cells, and then a different subpopulation of macrophages promotes tumor cell extravasation, survival, and subsequent growth. Specialized subpopulations of macrophages may represent important new therapeutic targets.

PMID:
20371344
PMCID:
PMC4994190
DOI:
10.1016/j.cell.2010.03.014
[Indexed for MEDLINE]
Free PMC Article

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