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FEBS Lett. 2010 Jun 18;584(12):2652-61. doi: 10.1016/j.febslet.2010.03.044. Epub 2010 Apr 3.

Cytokinesis and cancer.

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Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

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  • FEBS Lett. 2010 Sep 24;584(18):4128.


Cytokinesis is the final stage of cell division during which the two daughter cells separate completely. Although less well understood than some of the earlier phases of the cell cycle, recent discoveries have shed light on the mechanisms that orchestrate this process, including cleavage furrow formation, midbody maturation and abscission. One of the reasons why research on cytokinesis has been attracting increasing attention is the concept that failure of this process in mammals is associated with carcinogenesis. In this minireview, we will discuss the possible links between cytokinesis and cancer, and highlight key mechanisms that connect these processes.

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