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J Exp Med. 2010 Apr 12;207(4):677-80. doi: 10.1084/jem.20100523. Epub 2010 Apr 5.

Metabolism and the leukemic stem cell.

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1
Human Oncology and Pathogenesis Program Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Abstract

Acute leukemias are clonal disorders of hematopoiesis wherein a leukemic stem cell (LSC) acquires mutations that confer the capacity for unlimited self-renewal, impaired hematopoietic differentiation, and enhanced proliferation to the leukemic clone. Many recent advances in understanding the biology of leukemia have come from studies defining specific genetic and epigenetic abnormalities in leukemic cells. Three recent articles, however, further our understanding of leukemia biology by elucidating specific abnormalities in metabolic pathways in leukemic hematopoiesis. These studies potentially converge on the concept that modulation of reactive oxygen species (ROS) abundance may influence the pathogenesis and treatment of acute myeloid leukemia (AML).

PMID:
20368582
PMCID:
PMC2856035
DOI:
10.1084/jem.20100523
[Indexed for MEDLINE]
Free PMC Article
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