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Rejuvenation Res. 2010 Apr-Jun;13(2-3):373-7. doi: 10.1089/rej.2009.0980.

MicroRNA-regulated protein-protein interaction networks: how could they help in searching for pro-longevity targets?

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The Shraga Segal Department of Microbiology and Immunology, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer-Sheva, Israel.


In spite of enormous efforts and accumulated knowledge, our capabilities for tackling aging and age-related diseases (ARDs), and ultimately to promote longevity, are still very modest. What is lacking--essential data on key players, efficient analytic tools, or both? Here we discuss how the existing data may be integrated and analyzed in the context of microRNA (miRNA)-regulated protein-protein interaction networks. The proposed model highlighted: (1) The strong molecular links between aging, longevity, and ARDs; (2) the possibility and even the preferability of initiating longevity-promoting interventions in adult life; (3) the potentially important role for miRNA- (or small interfering RNA [siRNA]) mediated targeting of certain genes with features of antagonistic pleiotropy; (4) the superiority of systemic interventions to the common single-target approach in curing ARDs and promoting longevity.

[Indexed for MEDLINE]

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