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Phys Rev Lett. 2010 Jan 29;104(4):048101. Epub 2010 Jan 25.

Single-molecule rupture dynamics on multidimensional landscapes.

Author information

1
Department of Physics and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093, USA.

Abstract

We explore emergent effects of multidimensionality of the free energy landscape on single-molecule kinetics under constant force. The proposed minimal model reveals the existence of a spectrum of unusual scenarios for the force-dependent lifetime, all of which are shown to occur on a free energy landscape with a single transition state. We present an analytical solution that governs single-molecule responses to a constant force and relates them to microscopic parameters of the system.

PMID:
20366741
DOI:
10.1103/PhysRevLett.104.048101
[Indexed for MEDLINE]

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