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Nat Neurosci. 2010 May;13(5):615-21. doi: 10.1038/nn.2526. Epub 2010 Apr 4.

Neuropeptide feedback modifies odor-evoked dynamics in Caenorhabditis elegans olfactory neurons.

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1
Howard Hughes Medical Institute, The Rockefeller University, New York, New York, USA.

Abstract

Many neurons release classical transmitters together with neuropeptide co-transmitters whose functions are incompletely understood. Here we define the relationship between two transmitters in the olfactory system of C. elegans, showing that a neuropeptide-to-neuropeptide feedback loop alters sensory dynamics in primary olfactory neurons. The AWC olfactory neuron is glutamatergic and also expresses the peptide NLP-1. Worms with nlp-1 mutations show increased AWC-dependent behaviors, suggesting that NLP-1 limits the normal response. The receptor for NLP-1 is the G protein-coupled receptor NPR-11, which acts in postsynaptic AIA interneurons. Feedback from AIA interneurons modulates odor-evoked calcium dynamics in AWC olfactory neurons and requires INS-1, a neuropeptide released from AIA. The neuropeptide feedback loop dampens behavioral responses to odors on short and long timescales. Our results point to neuronal dynamics as a site of behavioral regulation and reveal the ability of neuropeptide feedback to remodel sensory networks on multiple timescales.

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PMID:
20364145
PMCID:
PMC2937567
DOI:
10.1038/nn.2526
[Indexed for MEDLINE]
Free PMC Article

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