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Mol Endocrinol. 2010 Sep;24(9):1703-14. doi: 10.1210/me.2009-0288. Epub 2010 Apr 2.

Minireview: Estrogen receptor-beta: mechanistic insights from recent studies.

Author information

1
The University of Western Ontario, Room A4-144, Children's Health Research Institute, 800 Commissioners Road East, London, Ontario, Canada N6C 2V5. bderoo2@uwo.ca

Abstract

The discovery of estrogen receptor-beta (ERbeta) in 1996 stimulated great interest in the physiological roles and molecular mechanisms of ERbeta action. We now know that ERbeta plays a major role in mediating estrogen action in several tissues and organ systems, including the ovary, cardiovascular system, brain, and the immune system, and that ERbeta and ERalpha generally play distinct physiological roles in the body. Although significant progress has been made toward understanding the molecular mechanisms of ERbeta action, particularly in vitro, there remains a large gap in our understanding of the mechanisms by which ERbeta elicits its biological functions in a true physiological context.

PMID:
20363876
PMCID:
PMC5417404
DOI:
10.1210/me.2009-0288
[Indexed for MEDLINE]
Free PMC Article

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