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Bioorg Med Chem Lett. 2010 May 1;20(9):2797-800. doi: 10.1016/j.bmcl.2010.03.062. Epub 2010 Mar 20.

Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a).

Author information

1
Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA. dboatman@arenapharm.com

Abstract

Tricyclic pyrazole tetrazoles which are potent partial agonists of the high affinity niacin receptor, GPR109a, have been discovered and optimized. One of these compounds has proven to be effective at lowering free fatty acids in vitro and in vivo.

PMID:
20363624
DOI:
10.1016/j.bmcl.2010.03.062
[Indexed for MEDLINE]

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