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Bioorg Med Chem Lett. 2010 May 1;20(9):2924-7. doi: 10.1016/j.bmcl.2010.03.025. Epub 2010 Mar 7.

Optimization of 7-alkene-3-quinolinecarbonitriles as Src kinase inhibitors.

Author information

1
Wyeth Research, Chemical Sciences 401 N. Middletown Road, Pearl River, NY 10965, United States. bosched@wyeth.com

Abstract

The 7-alkene-3-quinolinecarbonitrile 20, a potent inhibitor of Src enzymatic and cellular activity with IC(50) values of 2.1 and 58 nM, respectively, had comparable efficacy to bosutinib in a colon tumor xenograft study.

PMID:
20363128
DOI:
10.1016/j.bmcl.2010.03.025
[Indexed for MEDLINE]

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