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Fertil Steril. 2010 Jul;94(2):753.e11-4. doi: 10.1016/j.fertnstert.2010.01.035. Epub 2010 Apr 2.

Use of F 18-fluoro-D-glucose-positron emission tomography-computed tomography to localize a hilar cell tumor of the ovary.

Author information

1
Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1109, USA.

Abstract

OBJECTIVE:

To describe provocative testing and alternative imaging strategies used to localize an androgen-producing tumor in a 58-year-old woman with severe hirsutism.

DESIGN:

Case report.

SETTING:

Clinical Research Center.

PATIENT(S):

A 58-year-old woman who was seen for evaluation of severe hirsutism.

INTERVENTION(S):

Serum androgen levels were measured at baseline, 4 hours after administration of 2000 IU of hCG, and 11 days after administration of 3.75 mg of leuprolide acetate (LA). Magnetic resonance imaging and F 18-fluoro-D-glucose-positron emission tomography-computed tomography (FDG-PET/CT) were performed.

MAIN OUTCOME MEASURE(S):

Description of preoperative provocative testing and imaging.

RESULT(S):

In response to hCG, T rose from 243 to 288 ng/dL then decreased to 233 ng/dL after LA administration. The FDG-PET/CT scan demonstrated focal hypermetabolism in the right pelvis, corresponding to a soft-tissue density on the noncontrast CT scan. Magnetic resonance images were correlated with the PET/CT, and the right ovary was identified. Right salpingo-oophorectomy was performed, and final pathologic examination revealed a hilar cell tumor with ovarian cortical hyperplasia.

CONCLUSION(S):

This case demonstrates the utility of provocative testing in the evaluation of a patient with severe hirsutism and illustrates the value of FDG-PET/CT when traditional imaging is nondiagnostic.

PMID:
20362283
PMCID:
PMC2900497
DOI:
10.1016/j.fertnstert.2010.01.035
[Indexed for MEDLINE]
Free PMC Article

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