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Nat Rev Drug Discov. 2010 Apr;9(4):308-24. doi: 10.1038/nrd3012.

Carbohydrate vaccines: developing sweet solutions to sticky situations?

Author information

1
Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. rastrono@fhcrc.org

Abstract

Recent technological advances in glycobiology and glycochemistry are paving the way for a new era in carbohydrate vaccine design. This is enabling greater efficiency in the identification, synthesis and evaluation of unique glycan epitopes found on a plethora of pathogens and malignant cells. Here, we review the progress being made in addressing challenges posed by targeting the surface carbohydrates of bacteria, protozoa, helminths, viruses, fungi and cancer cells for vaccine purposes.

PMID:
20357803
PMCID:
PMC3878310
DOI:
10.1038/nrd3012
[Indexed for MEDLINE]
Free PMC Article

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