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Semin Immunol. 2010 Jun;22(3):132-43. doi: 10.1016/j.smim.2010.02.004. Epub 2010 Mar 30.

Whole tumor antigen vaccines.

Author information

1
Ovarian Cancer Research Center, University of Pennsylvania Medical Center, USA.

Abstract

Although cancer vaccines with defined antigens are commonly used, the use of whole tumor cell preparations in tumor immunotherapy is a very promising approach and can obviate some important limitations in vaccine development. Whole tumor cells are a good source of TAAs and can induce simultaneous CTLs and CD4(+) T helper cell activation. We review current approaches to prepare whole tumor cell vaccines, including traditional methods of freeze-thaw lysates, tumor cells treated with ultraviolet irradiation, and RNA electroporation, along with more recent methods to increase tumor cell immunogenicity with HOCl oxidation or infection with replication-incompetent herpes simplex virus.

PMID:
20356763
PMCID:
PMC3119500
DOI:
10.1016/j.smim.2010.02.004
[Indexed for MEDLINE]
Free PMC Article

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