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Psychopharmacology (Berl). 2010 Jun;210(3):337-46. doi: 10.1007/s00213-010-1828-5. Epub 2010 Mar 30.

Modafinil effects on reinstatement of methamphetamine seeking in a rat model of relapse.

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1
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.

Abstract

RATIONALE:

Modafinil (Provigil) is a wake-promoting drug characterized by cognitive enhancing abilities. Recent clinical data have supported the use of modafinil for treatment of chronic psychostimulant addiction and relapse prevention.

MATERIALS AND METHODS:

We used an intravenous methamphetamine (meth) self-administration procedure to assess the dose-dependent effects of modafinil on reinstatement following abstinence and after extinction on conditioned-cue and meth-primed reinstatement of meth seeking.

RESULTS:

Modafinil attenuated active lever responding in multiple reinstatement conditions-context-induced, conditioned cue, and meth prime. The most pronounced and consistent effect was on meth-primed reinstatement, and modafinil did not reinstate meth seeking when tested alone.

DISCUSSION:

These findings support clinical findings in humans that modafinil may be an effective therapeutic agent for the prevention of relapse in abstinent meth users.

PMID:
20352413
PMCID:
PMC3076899
DOI:
10.1007/s00213-010-1828-5
[Indexed for MEDLINE]
Free PMC Article
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