Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Genet. 1991 Feb;7(2):45-9.

Genomic imprinting in mammalian development: a parental tug-of-war.

Author information

  • 1MRC Experimental Embryology and Teratology Unit, St George's Hospital Medical School, London, UK.

Abstract

Genomic imprinting in mammals is increasingly being implicated in developmental and pathological processes, but without a clear understanding of its function in normal development. We believe that imprinting has evolved in mammals because of the conflicting interests of maternal and paternal genes in relation to the transfer of nutrients from the mother to her offspring. We present an hypothesis that accounts for many of the observed effects of imprinting in mammals and relates them to similar observations in plants. This hypothesis has implications for studies of X-chromosome inactivation and a range of human diseases.

PMID:
2035190
DOI:
10.1016/0168-9525(91)90230-N
[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center