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Antimicrob Agents Chemother. 2010 Jun;54(6):2738-40. doi: 10.1128/AAC.01546-09. Epub 2010 Mar 29.

Madurella mycetomatis is not susceptible to the echinocandin class of antifungal agents.

Author information

1
Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases' CE Rotterdam, The Netherlands. w.vandesande@erasmusmc.nl

Abstract

Eumycetoma caused by Madurella mycetomatis is treated surgically and with high doses of ketoconazole. Therapeutic responses are poor, and recurrent infections are common. In search of therapeutic alternatives in the treatment of mycetoma, we determined the in vitro susceptibilities of M. mycetomatis isolates against caspofungin, anidulafungin, and micafungin. As a comparator fungus, Aspergillus fumigatus was used. Minimal effective concentrations (MECs) and MICs were assessed and compared to those of ketoconazole. M. mycetomatis isolates were not susceptible to the echinocandins.

PMID:
20350944
PMCID:
PMC2876377
DOI:
10.1128/AAC.01546-09
[Indexed for MEDLINE]
Free PMC Article

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