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Neurogenetics. 2010 Jul;11(3):275-90. doi: 10.1007/s10048-010-0239-4. Epub 2010 Mar 27.

RNA processing pathways in amyotrophic lateral sclerosis.

Author information

1
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Abstract

RNA processing is a tightly regulated, highly complex pathway which includes RNA transcription, pre-mRNA splicing, editing, transportation, translation, and degradation of RNA. Over the past few years, several RNA processing genes have been shown to be mutated or genetically associated with amyotrophic lateral sclerosis (ALS), including the RNA-binding proteins TDP-43 and FUS/TLS. These findings suggest that RNA processing may represent a common pathogenic mechanism involved in development of ALS. In this review, we will discuss six ALS-related, RNA processing genes including their discovery, function, and commonalities.

PMID:
20349096
DOI:
10.1007/s10048-010-0239-4
[Indexed for MEDLINE]

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