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Heart Fail Clin. 2010 Apr;6(2):239-47. doi: 10.1016/j.hfc.2009.12.004.

Genetics of atrial fibrillation.

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1
Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract

Recent studies of atrial fibrillation (AF) have identified mutations in a series of ion channels; however, these mutations appear to be relatively rare causes of AF. A genome-wide association study has identified novel variants on chromosome 4 associated with AF, although the mechanism of action for these variants remains unknown. Ultimately, a greater understanding of the genetics of AF should yield insights into novel pathways, therapeutic targets, and diagnostic testing for this common arrhythmia.

PMID:
20347792
PMCID:
PMC3073057
DOI:
10.1016/j.hfc.2009.12.004
[Indexed for MEDLINE]
Free PMC Article
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