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Int J Parasitol. 2010 May;40(6):635-40. doi: 10.1016/j.ijpara.2010.02.008. Epub 2010 Mar 25.

Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia.

Author information

1
WHO Collaborating Centre for the Molecular Epidemiology of Parasitic Infections, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia.

Abstract

Australia is geographically isolated and possesses a remarkable diversity of wildlife species. Marsupials are highly susceptible to infection with the cosmopolitan parasite Toxoplasma gondii. Of 46 marsupials screened for T. gondii by multilocus PCR-DNA sequencing at polymorphic genes (B1, SAG3, GRA6, GRA7), 12 were PCR-positive; the majority (67%; 9/12) were infected by non-archetypal Type II-like or atypical strains. Six novel alleles were detected at B1, indicating greater diversity of genotypes than previously envisaged. Two isolates lethal to marsupials, were avirulent to mice. The data support the conclusion that Australia's isolation may have favoured the persistence of non-archetypal ancestral genotypes.

PMID:
20346947
PMCID:
PMC2864552
DOI:
10.1016/j.ijpara.2010.02.008
[Indexed for MEDLINE]
Free PMC Article

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