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Trends Biochem Sci. 2010 Jun;35(6):323-32. doi: 10.1016/j.tibs.2010.02.009. Epub 2010 Mar 24.

Polycomb group protein-mediated repression of transcription.

Author information

1
Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maal√łes Vej 5, 2200 Copenhagen, Denmark.

Abstract

The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.

PMID:
20346678
DOI:
10.1016/j.tibs.2010.02.009
[Indexed for MEDLINE]

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