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Breast Cancer Res. 2010;12(2):104. doi: 10.1186/bcr2483. Epub 2010 Mar 19.

Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?

Abstract

There is a strong association between BRCA1 mutation carrier status and estrogen receptor-negative breast cancer. This has led to the idea that estrogen receptor-positive breast cancers in BRCA1 mutation carriers may be incidental or sporadic in nature and not as a direct result of BRCA1 dysfunction. A recent paper in Breast Cancer Research challenges this view.

PMID:
20346095
PMCID:
PMC2879558
DOI:
10.1186/bcr2483
[Indexed for MEDLINE]
Free PMC Article

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