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FEBS J. 2010 May;277(9):2096-108. doi: 10.1111/j.1742-4658.2010.07623.x. Epub 2010 Mar 22.

Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.

Author information

1
Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.

Abstract

The protein arginine methyltransferase (PRMT) family of enzymes catalyzes the transfer of methyl groups from S-adenosylmethionine to the guanidino nitrogen atom of peptidylarginine to form monomethylarginine or dimethylarginine. We created several less polar analogs of the specific PRMT inhibitor arginine methylation inhibitor-1, and one such compound was found to have improved PRMT inhibitory activity over the parent molecule. The newly identified PRMT inhibitor modulated T-helper-cell function and thus may serve as a lead for further inhibitors useful for the treatment of immune-mediated disease.

PMID:
20345902
PMCID:
PMC2903848
DOI:
10.1111/j.1742-4658.2010.07623.x
[Indexed for MEDLINE]
Free PMC Article

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