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Acta Physiol (Oxf). 2010 Jun;199(2):149-60. doi: 10.1111/j.1748-1716.2010.02116.x. Epub 2010 Mar 24.

Signalling and pharmacological properties of the P2Y receptor.

Author information

1
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. tkh@med.unc.edu

Abstract

The P2Y(14) receptor is a relatively broadly expressed G protein-coupled receptor that is prominently associated with immune and inflammatory cells as well as with many epithelia. This receptor historically was thought to be activated selectively by UDP-glucose and other UDP-sugars. However, UDP is also a very potent agonist of this receptor, and may prove to be one of its most important cognate activators.

PMID:
20345417
PMCID:
PMC2913438
DOI:
10.1111/j.1748-1716.2010.02116.x
[Indexed for MEDLINE]
Free PMC Article

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