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Clin Infect Dis. 2010 May 1;50(9):1252-5. doi: 10.1086/651605.

Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts.

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1
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-3203, USA. memolim@niaid.nih.gov

Abstract

Pandemic 2009 H1N1 virus isolates containing the neuraminidase inhibitor resistance mutation H275Y have been reported. We describe rapid selection for the H275Y resistance mutation during therapy in 2 immunocompromised individuals at 9 and 14 days of therapy, as well as the first described case of clinically significant resistance to peramivir.

PMID:
20345239
PMCID:
PMC2946636
DOI:
10.1086/651605
[Indexed for MEDLINE]
Free PMC Article
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