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Cell Mol Life Sci. 2010 Jul;67(13):2195-213. doi: 10.1007/s00018-010-0324-8. Epub 2010 Mar 26.

The elegans of spindle assembly.

Author information

1
Medical Theoretical Center (MTZ), TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. mueller-reichert@tu-dresden.de

Abstract

The Caenorhabditis elegans one-cell embryo is a powerful system in which to study microtubule organization because this large cell assembles both meiotic and mitotic spindles within the same cytoplasm over the course of 1 h in a stereotypical manner. The fertilized oocyte assembles two consecutive acentrosomal meiotic spindles that function to reduce the replicated maternal diploid set of chromosomes to a single-copy haploid set. The resulting maternal DNA then unites with the paternal DNA to form a zygotic diploid complement, around which a centrosome-based mitotic spindle forms. The early C. elegans embryo is amenable to live-cell imaging and electron tomography, permitting a detailed structural comparison of the meiotic and mitotic modes of spindle assembly.

PMID:
20339898
PMCID:
PMC2883083
DOI:
10.1007/s00018-010-0324-8
[Indexed for MEDLINE]
Free PMC Article

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