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Adv Hematol. 2010;2010:137608. doi: 10.1155/2010/137608. Epub 2010 Mar 18.

Promyelocytic sarcoma of the spine: a case report and review of the literature.

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1
Hematology and BMT Unit, Institute of Hematotherapy, Ospedale S. Camillo, 00153 Rome, Italy.

Abstract

Myeloid sarcoma (MS, previously named granulocytic sarcoma or chloroma) is a rare extramedullary tumour of immature myeloid cells. It can be present before, concurrently with, or after the diagnosis of acute myeloid leukemia. MS is extremely uncommon in acute promyelocytic leukemia (APL). In the case described here, MS was the sole site of APL relapse and the cause of spinal cord compression. The patient presented with neurologic symptoms due to a paravertebral mass of MS after 7 years of complete remission. He was treated with excision of the mass followed by local radiotherapy. Systemic treatment was also given with combined arsenic trioxide and all-trans retinoic acid and the patient was able to achieve a second prolonged clinical and molecular remission.

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