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Diagn Microbiol Infect Dis. 2010 Jun;67(2):198-201. doi: 10.1016/j.diagmicrobio.2010.01.007. Epub 2010 Mar 24.

Molecular characterization of toxin A-negative, toxin B-positive variant strains of Clostridium difficile isolated in Korea.

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Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul 120-752, Korea.


A(-)B(+)Clostridium difficile strains are prevalent in Korea. We performed pulsed-field gel electrophoresis (PFGE), polymerase chain reaction ribotyping, and toxinotyping in 82 A(-)B(+) clinical isolates in Korea. PFGE showed highest discriminatory capability among the 3 methods. By PFGE, persistence of a clone was found, suggesting this clone has adapted to the hospital environment.

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