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Radiother Oncol. 2010 Oct;97(1):36-9. doi: 10.1016/j.radonc.2010.03.012. Epub 2010 Mar 24.

First report on the patient database for the identification of the genetic pathways involved in patients over-reacting to radiotherapy: GENEPI-II.

Author information

1
Department of Radiotherapy (Maastro Clinic), Maastricht University Medical Center, The Netherlands. dirk.deruysscher@maastro.nl

Abstract

BACKGROUND:

Identifying the most radiosensitive patient group would have huge clinical implications.

METHODS:

A tissue bank containing skin fibroblasts, whole blood, lymphocytes, plasma and lymphoblastoid cell lines from clinically radiation hypersensitive patients was established from patients in Europe and Canada. Over-reacting individuals had CTCAE3.0 severe acute side effects grade 2 or more occurring at very low radiation doses where these side effects are unexpected or grade 3-4 lasting more than 4 weeks after the end of radiotherapy and/or requiring surgical intervention at any time or severe late side effects grade 3-4.

RESULTS:

Eleven patients have been identified with a mean age of 61.6±8.5 years (range 49-74). Two patients were male, 9 female. One patient had non-small cell lung cancer, 6 breast cancer, 2 head and neck cancer, one lymphoma and one meningioma. The mean follow-up time after radiotherapy was 1658±1048 days (range 84-3752).

CONCLUSIONS:

The establishment of an international tissue bank of the rare group of patients with extreme hypersensitivity to radiotherapy was proven to be feasible and should enable in-depth molecular studies.

PMID:
20338650
DOI:
10.1016/j.radonc.2010.03.012
[Indexed for MEDLINE]
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