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Pediatr Allergy Immunol. 2010 Jun;21(4 Pt 1):564-76. doi: 10.1111/j.1399-3038.2010.01002.x. Epub 2010 Mar 19.

Perinatal nutrition and immunity to infection.

Author information

1
Department of Paediatrics, Imperial College, and Imperial College Healthcare NHS Trust, London, UK. kelsey.jones@imperial.ac.uk

Abstract

Epidemiological data provide strong evidence for a relationship between undernutrition and life-threatening infection in infants and children. However, the mechanisms that underlie this relationship are poorly understood. Through foetal life, infancy and childhood, the immune system undergoes a process of functional maturation. The adequacy of this process is dependent on environmental factors, and there is accumulating evidence of the impact of pre- and post-natal nutrition in this regard. This review outlines the impact of nutrition during foetal and infant development on the capacity to mount immune responses to infection. It provides an overview of the epidemiologic evidence for such a role and discusses the possible mechanisms involved.

PMID:
20337968
PMCID:
PMC2949400
DOI:
10.1111/j.1399-3038.2010.01002.x
[Indexed for MEDLINE]
Free PMC Article
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