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Curr Pharm Des. 2010 Jun;16(16):1826-42.

Natural product-inspired synthesis of thiazolidine and thiazolidinone compounds and their anticancer activities.

Author information

1
School of Chemistry and Chemical Engineering, Shandong University, Jinan, P R China.

Abstract

Nature makes many pharmacologically active compounds containing thiazolidine and thiazolidinone scaffolds. These privileged structures have been identified in many random screening assays. Molecules containing these core structures have been designed and synthesized, and they show a broad range of anticancer activities in vitro and in vivo. The combinatorial library approach has been demonstrated to be effective in lead discovery and optimization in order to improve the potency and toxicity of these compounds.

PMID:
20337578
DOI:
10.2174/138161210791208983
[Indexed for MEDLINE]

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