Abstract
Nature makes many pharmacologically active compounds containing thiazolidine and thiazolidinone scaffolds. These privileged structures have been identified in many random screening assays. Molecules containing these core structures have been designed and synthesized, and they show a broad range of anticancer activities in vitro and in vivo. The combinatorial library approach has been demonstrated to be effective in lead discovery and optimization in order to improve the potency and toxicity of these compounds.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anticarcinogenic Agents / adverse effects
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Anticarcinogenic Agents / chemical synthesis
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Anticarcinogenic Agents / pharmacology
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Biological Products / adverse effects
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Biological Products / chemistry*
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Biological Products / pharmacology*
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Combinatorial Chemistry Techniques
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Drug Design*
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Humans
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Thiazolidinediones / adverse effects
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Thiazolidinediones / chemical synthesis
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Thiazolidinediones / pharmacology
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Thiazolidines / adverse effects
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Thiazolidines / chemical synthesis*
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Thiazolidines / pharmacology*
Substances
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Anticarcinogenic Agents
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Antineoplastic Agents
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Biological Products
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Thiazolidinediones
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Thiazolidines