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Curr Pharm Des. 2010 Jun;16(16):1843-62.

Targeting protein tyrosine phosphatases for anticancer drug discovery.

Author information

1
Departments of Molecular Oncology and Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, FL 33612, USA.

Abstract

Protein tyrosine phosphatases (PTPs) are a diverse family of enzymes encoded by 107 genes in the human genome. Together with protein tyrosine kinases (PTKs), PTPs regulate various cellular activities essential for the initiation and maintenance of malignant phenotypes. While PTK inhibitors are now used routinely for cancer treatment, the PTP inhibitor development field is still in the discovery phase. In this article, the suitability of targeting PTPs for novel anticancer drug discovery is discussed. Examples are presented for PTPs that have been targeted for anticancer drug discovery as well as potential new PTP targets for novel anticancer drug discovery.

PMID:
20337577
PMCID:
PMC3076191
DOI:
10.2174/138161210791209027
[Indexed for MEDLINE]
Free PMC Article

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