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Folia Microbiol (Praha). 2010 Jan;55(1):61-7. doi: 10.1007/s12223-010-0010-0. Epub 2010 Mar 25.

Efficacy of Rhodotorula glutinis and Spirulina platensis carotenoids in immunopotentiation of mice infected with Candida albicans SC5314 and Pseudomonas aeruginosa 35.

Author information

1
Botany Department, Faculty of Science, Tanta University, Tanta 31527, Egypt. mostafaelsheekh@yahoo.com

Abstract

Enhancement of the immune response leading to protection against bacterial and fungal infections was shown using different schedules of immunization with microbial pigments and a polysaccharide. The group of mice given carotenoids of Rhodotorula glutinis (preparation I) and polysaccharide of Spitulina platensis (IV) survived for 2 weeks after Pseudomonas aeruginosa infection. The groups of mice given carotenoids (I), polysaccharide (IV), I+IV and with the crude phycocyanin of S. platensis (III)+IV survived for 2 weeks after Candida albicans infection. All other groups recorded a maximum level of mortality reaching 2 mice per group either after immunization or post-infection. Adding the carotenoids, phycocyanin and polysaccharides to food as additives might therefore enhance the human immune response against microbial infections.

PMID:
20336506
DOI:
10.1007/s12223-010-0010-0
[Indexed for MEDLINE]

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